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Course: Molecular Biophysics

Department/Abbreviation: KBF/SRZMB

Year: 2021

Guarantee: 'doc. RNDr. Martin Kubala, Ph.D.'

Annotation:

Course review:
Obligatory subjects: 1. Quantum physics Experiments that cannot be explained by classical physics. Postulates of the quantum mechanics. Mathematic formalism of the quantum mechanics. Harmonic oscilator. Perturbation theory. Hydrogen atom. Born-Oppenheimer approximation. Methods VB and LCAO. Quantum approach to the chemical bond. Multiple-atom molecules. 2. Experimental methods in Biophysics Principles of magnetic resonance. Nuclear magnetic resonance. Electron paramagnetic resonance. Experimental technique for measurement of magnetic resonance and application of magnetic resonance in biology. Mössbauer spectroscopy. Theory of the matter-and-light interaction. Classical and quantum theory of molecular vibrations. Molecular absorption. Dispersion- and FT-methods. Spectral lines broadening. 3. Molecular biology DNA replication. Transcription. Translation. Reverse transcription. Regulation of transcription. DNA-damage repair. DNA sequencing. DNA cloning. PCR. Use of microorganisms in molecular biology. Non-obligatory subjects (students seleck one of two) 4.A. Structural biology Structure of biomolecules (nucleic acids, proteins, lipids, sugars). Non-covalent interactions. Organization of cellular membranes. Membrane transport. Experimental methods for determination of structure of biomolecules. Examination of molecular dynamics. Detection of molecular interactions. Quantum chemical calculations. Homology of biopolymers. 4.B. Physiology Electron- and proton transfer in biology. Metabolic pathways in cellular respiration. Metabolism of proteins, sugas and fatty acids. Transmission and regulation of signals in living systems. Molecular mechanisms of sensing. Neurons, action potentials, EKG. Ionizable radiation in biology. Electrical methods in physiology. Gasometric and pressure methods in the plant physiology. Molecular principles of plant growth, development and stress.